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A positive family history further elevates risk, suggesting a genetic component

2.10 Autophagy assays To evaluate autophagy, microtubule-associated protein 1A/1Blight chain 3 (LC3) I to LC3II conversion and p62 protein degradation were measured using an immunoblot analysis as described below

Vincent Jacob A, Wieczerzak Krystyna B, Gabriel Hanna M, Nardelli P, Rich Mark M, Cope Timothy C (2016) A novel path to chronic proprioceptive disability with oxaliplatin: distortion of sensory encoding

These effects are attributed to indirect modulation of signaling pathways involved in cell survival rather than direct stimulation of neuronal activity

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